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Characteristic of metabolic disorders at patients with ischemic heart disease with various types of coronary arteries damage
2 Republican specialized centre of surgery named after academician V.Vakhidov, Tashkent, Uzbekistan
The article is devoted to the problems of metabolic disorders at ischemic heart disease (IHD). Changes of lipid’s, carbohydrate’s, purins’ metabolism parameters, markers of a system inflammation and oxidizing stress are analyzed at patients with ischemic heart disease with various types of coronary arteries damage (macro-, microvascular damage, absence of an organic stenosis). Materials and methods of research included the coronarоventriculography and laboratory tests data at 94 patients with ischemic heart disease. Results. It is established the prevalence of hyperuricemia and dyslipidemia at patients with ischemic heart disease with macrovascular damage of one or two coronary vessels. Hyperglycemia is established at patients with stenosis of 3 coronary arteries, hyperlipidemia is established at patients with microvascular damage of peripheral coronary vessels. The interrelation of oxidizing stress with the specified metabolic shifts, and also dependence of intensity of a system inflammation on the type of coronary arteries damage is established. It is shown, that hyperfibrinogenemia, hyperuricemia, hypertrigliceridemia, dislipidemia and high body mass index are accompanied with endogenous intoxication, high level of radical oxygen species in the patients without organic stenosis of coronary vessels. These combination of metabolism disorders is powerful factor of IHD development in the patients without organic defeat of coronary vessels.
ischemic heart disease, oxidizing stress, hyperuricemia, hyperlipidemia, macrovascular and microvascular damage of coronary arteries
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