Science for Education Today, 2021, vol. 11, no. 5, pp. 142–156
© Novikova I. I., Ogudov A. S., Shevkun I. G., Serenko E. V., Chuenko N. F., Gavrish S. M., Semenikhina M. V., Kryuchkova N. Y., 2021
UDC: 
613.26+613.03+616.08+378

Anti-inflammatory, hypoglycemic and hypolipidemic effects of Stevia rebaudiana bertoni leaf extract in an experimental model of diabetes mellitus and obesity in laboratory animals

Novikova I. I. 1 (Novosibirsk, Russian Federation), Ogudov A. S. 1 (Novosibirsk, Russian Federation), Shevkun I. G. 2 (Moscow, Russian Federation), Serenko E. V. 1 (Novosibirsk, Russian Federation), Chuenko N. F. 1 (Novosibirsk, Russian Federation), Gavrish S. M. 1 (Novosibirsk, Russian Federation), Semenikhina M. V. 1 (Novosibirsk, Russian Federation), Kryuchkova N. Y. 3 (Omsk, Russian Federation)
1 Federal Budgetary Institution of Science "Novosibirsk Research Institute of Hygiene" of the Federal Service for Supervision of Consumer Rights Protecti
2 Department of Sanitary Supervision of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
3 Budgetary Institution of Continuing Professional Education of the Omsk region «Center for the Advanced Training of Healthcare Workers»
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Abstract: 

Introduction. The paper presents the results of experimental studies focused on assessing the anti-inflammatory, hypoglycemic and hypolipidemic effects of Stevia rebaudiana Bertoni leaf extract. The study was conducted on an experimental model of "zinc" diabetes in white male Wistar rats and under conditions of acute hyperlipidemia caused by the Tween-80 detergent.
The aim of the study was to evaluate the feasibility of using Stevia rebaudiana Bertoni leaf extracts in the diet as a natural sweetener for the organizing nutrition of overweight and diabetic people, including educational settings for children, on the model of induced diabetes mellitus and acute hyperlipidemia in laboratory animals.
Materials and Methods. In order to solve the research problem, the authors utilized the following techniques: assessing the biochemical parameters of blood serum, determining the level of glucose in the blood, lipid formula and delayed-type hypersensitivity reaction. Theoretical methods involved reviewing and analyzing Russian and international academic articles.
Results. The findings of this study suggest that it is possible to use Stevia rebaudiana Bertoni leaf extracts as a natural sugar substitute in the diet of people with overweight and diabetes mellitus, as well as for prophylaxis in healthy people, including meals for children in educational settings.
Conclusions. The article concludes that an immunomodulatory effect and the absence of side effects of the Stevia rebaudiana Bertoni leaf extract confirm its usage in the daily diet of the population.

Keywords: 

Stevia rebaudiana Bertoni; Stevia; Twin-80; Dithizon; Diabetes mellitus; Healthy eating; Food hygiene; Hyperlipidemia; Obesity; Delayed-type hypersensitivity.

URL WoS/RSCI: https://www.webofscience.com/wos/rsci/full-record/RSCI:47136063

For citation:
Novikova I. I., Ogudov A. S., Shevkun I. G., Serenko E. V., Chuenko N. F., Gavrish S. M., Semenikhina M. V., Kryuchkova N. Y. Anti-inflammatory, hypoglycemic and hypolipidemic effects of Stevia rebaudiana bertoni leaf extract in an experimental model of diabetes mellitus and obesity in laboratory animals. Science for Education Today, 2021, vol. 11, no. 5, pp. 142–156. DOI: http://dx.doi.org/10.15293/2658-6762.2105.08
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Date of the publication 31.10.2021