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System analysis of the effectiveness of compositions of antioxidants in low doses for the correction of oxidative stress at toxic-septic conditions
The investigation aim was to study the possibilities of choice of rational songs antioxidants metabolic action of low doses in laboratory tests in vitro, as well as assessment of their efficiency at the correction of oxidative stress in experimental modeling toxic-septic conditions in vivo, such as endotoxin shock, using the criteria of optimality of decisions under uncertainty. Metabolic correctors of antioxidant action, ensuring the normalization of prooxidative and antioxidative processes, as well as correction of violations of thermal homeostasis at bacterial endotoxin shock were characterized.
oxidative stress, antioxidants, metabolic correction, decision-making criteria, system analysis
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