Novosibirsk State Pedagogical University Bulletin, 2013, vol. 3, no. 5, pp. 43–65
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Antioxidant activity of some preparations, obtained on the basis of Kazakhstani plants

Zhusupova G. 1 (Almaty, Republic of Kazakhstan), Shalakhmetova T. 1 (Almaty, Republic of Kazakhstan), Murzakhmetova M. 2 (Almaty, Republic of Kazakhstan), Gadetskaya A. 1 (Almaty, Republic of Kazakhstan), Zhusupova A. 1 (Almaty, Republic of Kazakhstan)
1 Al-Farabi Kazakh National University
2 Institute of Human and Animal Physiology
Abstract: 

The paper shows the distribution of "free radical pathology" (diseases of the cardiovascular system, gastrointestinal tract, malignancy), which is the result of reducing the protective capacity of the organism; comparative analysis of some features of preparations of synthetic and natural origin, used for the elimination of this disease, is given. Aim of the article – is to characterize the antioxidant effect of herbal preparations, obtained on the basis of Kazakhstani plants. It is noted that the stocks of used plants have recoverable reserves in the country, obtaining preparations on their basis is economically and environmentally beneficial, and most important is that their action must be commensurate with the efficiency of global analogues, without causing side effects in the body. While many antioxidant and hepatoprotective drugs currently used in clinical practice are synthetic, costly, cause allergic reactions and possess pronounced cumulative properties. Therefore, in pharmacotherapy and disease prevention of "free radical pathology", herbal medicinal products become important, the effect of which is based on a synergistic action of the major classes of natural compounds, such as polyphenols, amino and phenolic acids, higher carboxylic acids of polyene series, vitamins and microelements. Finally, conclusions are drawn, which characterize the preferred use of natural preparations in medicine in view of their bioavailability, low toxicity, absence of allergic and cumulative reactions, and by virtue of this, the possibility of their prolonged use in the treatment and prevention of several diseases.

Keywords: 

Kazakhstani plants, antioxidant activity, plants of Limonium Mill genus, Limonium gmelinii, Limonium. myrianthum of Plumbagenaceae family, Cuscuta campestris Juncker

For citation:
Zhusupova G., Shalakhmetova T., Murzakhmetova M., Gadetskaya A., Zhusupova A. Antioxidant activity of some preparations, obtained on the basis of Kazakhstani plants. Novosibirsk State Pedagogical University Bulletin, 2013, vol. 3, no. 5, pp. 43–65.
References: 

1. Droge W. Free Radicals in the Physiological Control of Cell Function. Physiol. Rev., 2002, vol. 82, no. 1, pp. 47–95.
2. Kehrer J.P., Robertson J.D. and Smith C.V. Free Radicals and Reactive Oxygen Species. Comprehensive Toxicology, 2010, vol. 1, pp. 277–307.
3. Halliwel B. Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life. Plant. Physiology, 2006, vol. 141, pp. 312–322.
4. Halliwel B. Antioxidants in human health and disease. Annu. Rev. Nutr., 1996, vol. 16, pp. 33–50.
5. Valko M., Leibfritz D., Moncola J., Cronin M.T.D., Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry & Cell Biology, 2007, vol. 39, pp. 44–84.
6. Storz P. Reactive oxygen species in tumo progression. Front. Biosci., 2005, vol. 10, pp. 1881–1896.
7. Rice-Evans C. A., Diplock A. T. Current status of antioxidant therapy. Free Radic. Biol. Med., 1993, vol. 15, no. 1, pp. 77–96.
8. Sies H. Oxidative stress: Oxidants and antioxidants. Exp. Physiol., 1997, vol. 82, no. 2, pp. 291–295.
9. Cuzzorcrea S., Thiemermann C., Salvemini D. Potential therapeutic effect of antioxidant therapy in shock and inflammation. Curr. Med. Chem., 2004, vol. 11, pp. 1147–1162.
10. Manach C., Scalbert A., Morand C., Rémésy C. and Jiménez L. Polyphenols: food sources and bioavailability. Am. J. Clin. Nutrition., 2004, vol. 79, no. 5, pp. 727–747.
11. Boudet A. M. Evolution and current status of research in phenolic compounds. Phytochemistry, 2007, vol. 68, no. 22–24, pp. 2722–2735.
12. Manach C., Mazur A., Scalbert A. Polyphenols and prevention of cardiovascular diseases. Curr. Opin. Lipidol., 2005, vol. 16, no. 1, pp. 77–84.
13. Arts I.C., Hollman P.Ch. Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr., 2005, vol. 81, no. 1, pp. 317S–325S.
14. Molan A. L., Waghorn G. C, Min B. R., McNabb W. С. The effect of condensed tannins from seven herbages on Trichostrongy luscolubri for mislarval migration in vitro. Folia Parasitol., 2000, vol. 47, no. 1, pp. 39–44.
15. Bo Z., Zhi-Sheng J., Zhi-Hua C., Li Y., Long-Min W., Zhong-Li L. Synergetic antioxidant effect of green tea polyphenols with 0–tocopherol on the radical induced peroxidation of linoleic acid in micelles. J. Chem. Soc., 2000, vol. 4, pp. 785–791.
16. Lin J.-K., Liang Y.-C. Cancer chemoprevention by tea polyphenols. Proc. Natl. Sci. Counc., 2000, vol. 24, pp. 1–13.
17. De Freitas V., Mateus N. Structural features of procyanidin interactions with salivary proteins. J. Agr. and Food Chem., 2001, vol. 49, no. 2, pp. 940–945.
18. Scalbert A. Antimicrobial properties of tannins. Phytochem., 1991, vol. 30, no. 12, pp. 3875–3883.
19. Verstraeten S.V., Keen C.L., Schmitz H.H., Fraga C.G. and Oteiza P.I.Flavan–3–ols and procianidins protect liposomes against lipid oxidation and disruption of the bilayer structure. Free Radic. Biol. Med., 2003, vol. 34, no. 1, pp. 84–92.
20. Nagai T., Miyachi Y., Tomimori T., Yamada H. Inhibition of influenza virus sialidase and anti–influenza virus activity by plant flavonoids. Chem. Pharm. Bull., 1990, vol. 5, no. 38, pp. 1329–1332.
21. Petereit F., Kolodziej H., Nahrsted A. Flavan-3-ols and proanthocyanidins from Cistusincanus. Phytochem., 1991, vol. 30, no. 3, pp. 981–985.
22. Herbs of Kazakhstan and their use. Almaty, 1996, 344 p.
23. Flora of the USSR. Moscow, 1952. XVIII. pp. 411–467.
24. Flora of Kazakhstan. Alma-Ata: Science Publ., 1961. VII. pp. 79–80.
25. The Atlas of areas and resources of herbs of Kazakhstan. Almaty, 1994. p. 41.
26. Kukenov M.K. Botanical resources of Kazakhstan. Almaty, 1999. 160 p.
27. Sivertsev I.I., Abakumov L.F. Pharmacological studying and medical application of kermek preparations. News of Kazakhstan academy of sciences. A series the physiologist, 1950, vol. 3, pp. 75–88.
28. Klyshev L.K., Аlyukina L.S. Materials to a question of studying of tannic industrial kinds of kermek (Staticegmelinii Wild. Staticemyrianthum Schrenk). News of Kazakhstan academy of sciences, 1951, no. 5, pp. 99–104.
29. Pavlov N.V. Vegetative raw material of Kazakhstan. Moscow, 1947. 552 p. (In Russian)
30. Mihailova V.P. Tannic of a plant of flora of Kazakhstan and their development. Alma-Ata: Science Publ., 1968. 326 p.
31. Аlyukina L.S. Flavonoid and tanidplants of Kazakhstan. Alma-Ata: Science Publ., 1977. 152 p.
32. Chumbalov T.K. Chemical research of substances of some plants of Kazakhstan tannic and accompanying them. Tashkent, 1966. 26 p.
33. Dostanova R.H. Phenol complex of plants at salt ofenvironments. Novosibirsk, 1994. 34 p. (In Russian)
34. Vegetativeresources of the USSR. Leningrad: Science Publ., 1985. vol.1, pp. 293–297. (In Russian)
35. Asen S., Plimmer J. R. 4,6,4'–trihydroxyaurone and other flavonoids from Limonium. Phytochem, 1972, vol. 11, pp. 2601–2603.
36. LarherF., Hamelin J. L’acide β–trimethylamminopropioniquelesrameauxdeLimoniumVulgareMill. Phytochem, 1975, vol. 14, no. 1, pp. 205–207.
37. LarherF., Hamelin J. Miseenevidencede L’acide 2–trimethylamino–6–cetoheptanoiquedanslesrameauxde LimoniumVulgare. Phytochem, 1975, vol. 14, no. 8, pp. 1789–1791.
38. Ross S. A., El-Sayyad S. M. Flavonoids from the leaves of Limoniumsiniatum grown in Egypt. Planta Med., 1980, vol. 39, no. 2, pp. 187–189.
39. Ross S. A. Myricetin-3’-methyl ether-7-glucoside from Limoniumsinuatum. J. Natur. Prod., 1984, vol. 47, pp. 862–864.
40. Lin L. C., Kuo Y. C., Chou C. J. Anti-herpes simplex virus type–1 flavonoids and new flavone from the root of Limoniumsinense. Planta Med., 2000, vol. 66, pp. 333–336.
41. Lin L. C., Chou C. J. Flavonoids and phenolics from Limoniumsinense. Planta Med., 2000, vol. 66, pp. 382–383.
42. Movsumov I. S. Flavonoids of roots Limoniumcaspium. Chemistry of natural connections, 1996, no. 6, p. 948. (In Russian)
43. Zhang L.-R., Zou G.-L. Flavanolof Limoniumbicolor. Chemistry of natural connections, 2004, no. 6, p. 495.
44. Harborne J. B.Соmparative biochemistry of the flavonoids–IV. Correlation between chemistry, pollen morphology and systematics in the family Рlumbaginaceae. Phytochem., 1967, vol. 6, pp. 1415–1428.
45. Zhusupova G. E. Kermeka Gmelina rhizomes and roots. The state pharmacopoeia of Republic Kazakhstan. Almaty, 2009, vol. 2, pp. 706–707.
46. Zhusupova G. E., Abilkaeva S. A. Dimericprodelphinidins from Limoniumgmelinii roots. III. Chemistry of Natural Compounds, 2006, no. 2, pp. 134–138. http://dx.doi.org/10.1007/ s10600–006–0068–8.
47. Zhanar A. Kozhamkulova, Galiya E. Zhusupova, Zharilkasin A. Abilov, Mohamed M. Radwan, Samir A. Ross. A New Flavonol Glycoside from Limonium gmelinii. Planta medica, 2010, pp. 534–535.
48. Vengerovskij A. I., Saratikov A. S. Mechanism of action of gepatoprotektors at toxic defeats of a liver. Pharmacology and toxicology, 1988, no. 1, p. 89. (In Russian)
49. Kala C. P., Farooquee N. A., Dhar U. Prioritization of medicinal plants on the basis of available knowledge, existing practices and use value status in Uttaranchal, India. Biodiver. Conserv., 2004, vol. 13, no. 2, pp. 453–469.
50. Gorgoshidze L. S., Kon I. J., Kulakov S. N., Shevyakov A. N. Peroxide oxidation of lipids in a liver of rats at not heavy forms of insufficiency of vitamin A. Questions of a feed, 1986, vol. 5, pp. 45–51. (In Russian)
51. Ohkawa H.O., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 1979, vol. 95, no. 2, pp. 351–358.

Date of the publication 26.10.2013