Novosibirsk State Pedagogical University Bulletin, 2017, vol. 7, no. 1, pp. 216–229
© Nedovesova S. A., Trofimovich E. M., Turbinsky V. V., Aizman R. I., 2017
UDC: 
612+59

The effect of long-term consumption of drinking water with increased magnesium content on renal functions at animals

Nedovesova S. A. 1 (Novosibirsk, Russian Federation), Trofimovich E. M. 2 (Novosibirsk, Russian Federation), Turbinsky V. V. 3 (Novosibirsk, Russian Federation), Aizman R. I. 1 (Novosibirsk, Russian Federation)
1 Novosibirsk State Pedagogical University, Novosibirsk, Russian Federation
2 Novosibirsk State Pedagogical University
3 Novosibirsk Research Institute of hygiene of the Federal service for supervision of consumer rights protection and human welfare, Novosibirsk, Russian Federation
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Abstract: 

Introduction. In the literature there are contradictory data on the effect of hardness of drinking water due to high concentration of magnesium and calcium salts on different organs and systems. The aim of the study was to investigate the effect of prolonged consumption of drinking water with increased content of Mg2+ on renal functions in animals.
Materials and Methods. Sexually mature Wistar rats of 3 groups during 6 months received drinking water with different content of Mg2+ ions (5 mg/dm3 – control, 35 mg/dm3 – the 1-st group and 70 mg/dm3 – the 2-nd group). To study the renal functions at the 1st, 4th and 6th month the background urine samples within 4 hours and 3 hours after oral intake of 5% of body weight water loads were collected. At the beginning and the end of the experiment, blood was collected to estimate the homeostatic parameters and plasma concentrations of stress hormones (corticosterone, thyrotropin, thyroxine and triiodothyronine). Using the methods of flame photometry, cryoscopy, biochemical and immunoassays the concentrations of electrolytes, osmotically active substances and hormones in urine and plasma were determined. The calculation of urine, osmo- , and ionregulating renal functions was performed by standard formulas.
Results. It was shown that prolonged intake of water with increased concentration of Mg2+ caused adaptive changes of osmo- and ionoregulating renal response, characterized by its voltage during the first 4 months, especially in conditions of relative rest and high content of Mg2+ (70 mg/dm3): diuresis reduction, the rise in the relative reabsorption of fluid, the osmolarity of urine and excretion of ions, – so the serum parameters remained within homeostatic level. To the 6th month of experiment the ion-osmotic parameters of plasma and urine in all groups of animals were practically identical. However, it was the decrease of the concentration of stress hormones compared to the control, especially in the 2nd group, which could be due to depletion of hormonal mechanisms responsible for adaptive adjustment of the organism to the drinking water.
Conclusions. Long-term consumption of drinking water with high content of Mg2+ causes adaptive adjustment of hormonal and renal responses, the value of which depends on the concentration of ion in the water and the duration of the consumption time.

Keywords: 

Magnesium; drinking water; renal functions; diuresis; glomerular filtration rate; ionuretic renal response; hormones; blood plasma

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The effect of long-Term consumption of drinking water with increased magnesium content on renal functions in animals

For citation:
Nedovesova S. A., Trofimovich E. M., Turbinsky V. V., Aizman R. I. The effect of long-term consumption of drinking water with increased magnesium content on renal functions at animals . Novosibirsk State Pedagogical University Bulletin, 2017, vol. 7, no. 1, pp. 216–229. DOI: http://dx.doi.org/10.15293/2226-3365.1701.15
References: 
  1. Avdeeva T. G. The influence of the composition of drinking water on the health of children. Poliklinika. 2006, no. 1, pp. 62–63.  (In Russian)
  2. Bulatov V. P., Ivanov A. V., Rylova N. V. Effect of prolonged consumption of drinking water with unfavourable mineral composition. Pediatrics.  2004, no. 1, pp. 71–74.  (In Russian)
  3.  Gladkevich A. C., Śnieżnik V. A., Tishkovsky S. V., Adomaitiene V. et al. The role of magnesium in the pathogenesis of depressive disorders, some comorbid diseases and ways of their correction. Journal of Grodno State Medical University. 2016, vol. 52, no. 4, pp. 15–25. (In Russian)
  4. Govorin A. V., Filev A. P. Drugs of magnesium in diseases of the cardiovascular system. Actual problems of clinical pharmacology. 2012, no. 8 (3), pp. 463–468. (In Russian)
  5. Gorbachev A. L. Elemental status of population in connection with the chemical composition of drinking water. Trace elements in medicine. 2006, vol. 7, issue 2, pp. 11–24. (In Russian)
  6. Gregus J. I., Mikhailova O. D., Gorbunov Y. A., Vakhrushev Ya. M. The value of magnesium in the physiology and pathology of the digestive system.  Experimental and clinical gastroenterology. 2015, vol. 118, no. 6, pp. 89–94. (In Russian)
  7. Zinoviev V. N., Yesica I. N., Spasov A. A. Magnesium homeostasis: mechanisms and inherited disorders. Biomed. 2007, vol. 53, no. 6, pp. 683–704. (In Russian)
  8. Lysikov Yu. A. Role and physiological basis of exchange of macro - and microelements in human nutrition. Experimental and clinical gastroenterology. 2009, no. 2, pp. 120–131. (In Russian)
  9. Maslov D. V., Nechaeva E. M., Afanasiev-Grigoriev S. I. et al. Hygienic estimation of quality of centralized drinking water supply in Primorsky Krai. Results and prospects of scientific researches on the problem of human ecology and environmental hygiene. Moscow, 2005, pp. 174–179. (In Russian)
  10. Wise I. V. The influence of mineral composition of drinking water on human health (a review). Hygiene and sanitary. 1999, no. 1, pp. 15–18. (In Russian)
  11. Onishchenko G. G., Zaitseva N. V., Mai I. V., Andreev E. E. Cluster systematization of parameters of sanitary and epidemiological welfare of the population of the regions and cities of Federal importance. Preventive medicine: current aspects of health risk analysis. 2016, no. 1 (13), pp. 4–14. (In Russian)
  12. Pantyukhin I. V., Finkinshtein Ya. D. Reflex mechanisms maintaining magnesium homeostasis. Bulletin of experimental biology and medicine. 1977, vol. 84, no. 7, pp. 7–11. (In Russian)
  13. Polyakov V. Y., Revutskaya I. L., Surits O. V. The worsening of calcium and magnesium deficit in drinking water of Birobidzhan at the ion exchange deferrisation. Human Ecology. 2016, no. 9, pp. 3–9.  (In Russian)
  14. Ulubieva E. A., Avtandilov A. G. The effect of magnesium on the cardiovascular system in women. Rational pharmacotherapy in cardiology. 2016, vol. 12, no. 1, pp. 87–93. (In Russian)
  15.  Shuckaya J. V., Shakhmatova E. I., Kuznetsova A. A., Natochin Yu. V. Role of kidneys in regulation of osmolality and concentrations of cations in the blood serum in hyperglycemia. Human Physiology. 2008, no. 5 (34), pp. 73–79. (In Russian)
  16. Blaine J., Chonchol M., Levi M. Renal control of calcium, phosphate, and magnesium homeostasis. Clinical Journal of the American Society of Nephrology. 2015, no. 10 (7), pp. 1257–1272. DOI: http://dx.doi.org/10.2215/CJN.09750913
  17. Catling L. A., Abubakar I., Lake I. R. et al. A systematic review of analytical observational studies investigating the association between cardiovascular disease and drinking water hardness. J. Water Health. 2008, vol. 6, no. 4, pp. 433–442. DOI: http://dx.doi.org/10.2166/wh.2008.054.
  18. Chubanov V., Ferioli S., Wisnowsky A., Simmons D. G., Leitzinger C. et al. Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Biophysics and Structural Biology. 2016, vol. 3, pp. 1–32. DOI: http://dx.doi.org/10.7554/eLife.20914
  19. Floege J. Magnesium in CKD: more than a calcification inhibitor? Journal of Nephrology. 2015, no. 28 (3), pp. 269–277. DOI: http://dx.doi.org/10.1007/s40620-014-0140-6
  20. Houillier P. Mechanisms and regulation of renal magnesium transport.  Annual Review of Physiology. 2014, no. 76, pp. 411–430. DOI: http://dx.doi.org/10.1146/annurev-physiol-021113-170336
  21. Khan A. M. et al. Low serum magnesium and the development of atrial fibrillation in the community: the Framingham Heart Study. Circulation. 2013, vol. 127, pp. 33–38. DOI: http://dx.doi.org/10.1161/CIRCULATIONAHA.111.082511
  22. Leurs L. J., Schouten L. J., Mons M. N. et al. Relationship between tap water hardness, magnesium and calcium concentration and mortality due to ischemic heart disease or stroke in The Netherlands. Envirom. Health Perspect. 2010, vol. 118, no. 3, pp. 414–420. DOI: http://dx.doi.org/10.1289/ehp.0900782
  23. M. de Francisco A. L., Rodraguez M. Magnesium and its role in CKD. Nefrologia: publicacion oficial de la Sociedad Espanola Nefrologia. 2013, vol. 33, no. 3, pp. 389–399. DOI: http://dx.doi.org/10.3265/Nefrologia.pre2013.Feb.11840
  24. Morris R. W., Walker M., Lennon L. T. et al. Hard drinking water does not protect against cardiovascular disease: new evidence from the British Regional Heart Study. Eur. J. Cardiovasc. Prev. Rehabil. 2008, vol. 15, no. 2, pp. 185–189. DOI: http://dx.doi.org/10.1097/HJR.0b013e3282f15fce
  25. Romani A. Regulation of magnesium homeostasis and transport in mammalian cells. Archives of Biochemistry and Biophysics. 2007, issue 1, vol. 458, pp. 90–102. DOI: http://dx.doi.org/10.1016/j.abb.2006.07.012
  26. Trisvetova A. L. Magnesium in clinical practice. Rational Pharmacotherapy in Cardiology. 2016, vol. 8, no. 4, pp. 545–553.
  27. Van der Wijst J., Bindels R. J., Hoenderop J. G. Mg2+ homeostasis: the balancing act of TRPM6. Current opinion in nephrology and hypertension. 2014, no. 23 (4), pp. 361–369. DOI: http://dx.doi.org/10.1097/01.mnh.0000447023.59346.ab
  28. Whyte K. F. et al. Adrenergic control of plasma magnesium in man. Clin. Science (Lond). 1987, vol. 72, no. 1, pp. 135–138.
Date of the publication 25.02.2017