Novosibirsk State Pedagogical University Bulletin, 2016, vol. 6, no. 3, pp. 167–175
© Kozlova A. P., Koroshchenko G. A., Aizman R. I., 2016
UDC: 
591.133 + 591.149.2

What components of plant curcuma longa provide hypoglycemic effect in diabetes mellitus?

Kozlova A. P. 1 (Novosibirsk, Russian Federation), Koroshchenko G. A. 1 (Novosibirsk, Russian Federation), Aizman R. I. 2 (Novosibirsk, Russian Federation)
1 Novosibirsk State Pedagogical University
2 Novosibirsk State Pedagogical University, Novosibirsk, Russian Federation
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Abstract: 

The aim of the study is to identify the components of the plant Curcuma longa that provide hypoglycemic effect in diabetes. It is shown that the active principle of turmeric - curcumin, as well vitamins, included in its composition, and artificial antioxidant "Selenofan" imitating the antioxidant properties of all the compounds of turmeric, caused the hypoglycemic effect in alloxan model of diabetes in rats, which level was most pronounced under the influence of antioxidants. One of the mechanisms for reducing the glucose concentration in the blood plasma of animals with alloxan-induced diabetes was the elevation of the glycogen content in the liver of rats. The level of such glycogen increase was dependent on the used substance. Thus, the hypoglycemic effect of turmeric is due not only to the separate components, but to the presence in the plant of the biological active substances with antioxidant action that confirms the feasibility of its use in the treatment of studied pathology.

Keywords: 

carbohydrate metabolism, diabetes, rat, alloxan, turmeric, curcumin, vitamins C and E, antioxidants, selenofan

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What components of plant curcuma Longa provide hypoglycemic effect in diabetes mellitus?

For citation:
Kozlova A. P., Koroshchenko G. A., Aizman R. I. What components of plant curcuma longa provide hypoglycemic effect in diabetes mellitus?. Novosibirsk State Pedagogical University Bulletin, 2016, vol. 6, no. 3, pp. 167–175. DOI: http://dx.doi.org/10.15293/2226-3365.1603.15
References: 
  1. Barnaulov O. D. Comparative evaluation of the effect of herbal remedies from plants flora Russia on blood glucose and insulin concentrations in rats with experimental alloxan diabetes. Psychopharmacology and Biological narkologiya. 2008, vol. 8, Iss. 3-4, pp. 2484–2490. (In Russian)
  2. Bondar I. A., Klimantov V. V. The antioxidants in the treatment and prevention of diabetes mellitus. Diabetes mellitus. 2001, no. 1, pp. 47–52. (In Russian)
  3. Gaydarova A. P., Koroshchenko G. A., Aizman R. I. Effect of turmeric and curcumin on carbohydrate metabolism in alloxan-induced diabetes in rats. Modern problems of science and education. 2014, no. 5, pp. 597. (In Russian)
  4. Jafarova R. E., Garayev G. Sh., Dzhafarkulieva Z. S. Leaf extract, bilberry Actions for a pathological process alloxan-induced diabetes mellitus. Basic Research. 2010, no. 4, pp. 36–43. (In Russian)
  5. Jafarova R. E. Learning actions phytocomplex "anti-diabetes" and collect "Mirfazin" on blood sugar levels and plasma glycogen in liver and muscle. Journal of Russian Military Medical Akademy. 2013, no. 4 (44), pp. 172–174. (In Russian)
  6. Koroshchenko G. A., Gaidarova A. P., Aizman R. I., Subotyalov M. A. The possibility of using herbal remedies to maintain homeostasis in the pathology. Ukrainian Biopharmaceutical Journal. 2014, no. 4 (33), pp. 45–49. (In Russian)
  7. Koroshchenko G. A., Subotyalov M. A., Gerasev A. D., Aizman R. I. Influence of rootstock plants Surcuma longa on carbohydrate metabolism in rats in the experiment. The Bulletin Siberian Branch of Russian Academy of Medical Sciences. 2011, vol. 31, no. 3, pp. 92–96. (In Russian)
  8. Soguyko Y. R., Krivko Y. Y., Barker E. N., Novikov O. O. Morphofunctional characteristic liver of rats in normal and diabetes mellitus in an experiment. Modern problems of science and education. 2013, no. 1, p. 52. (In Russian)
  9. Sumbul S., Khan M. S., Bano B. Action of curcumin on the nitric oxide-induced structural and functional modifications of the high cystatin brain goats. Biomeditsinskaya Khimiya. 2010, vol. 56, no. 2, pp. 209–219. (In Russian)
  10. Aizman R. I., Koroshchenko G. A., Gaidarova A. P., Lukanina S. N., Subotyalov M. A. The mechanisms of plant rhizome curcuma longa action on carbohydrate metabolism in alloxan – induced diabetes mellitus rats. American Journal of Biomedical Research.  2015, vol. 3, no. 1, рр. 1–5.
  11. Eidi M. Effect of corianderseed (Coriandrum sativum L.) ethanol extract on insulin release from pancreatic beta cells in streptozotocin-induccd diabetic rats. Phytotherapy Research. 2009, vol. 23, no. 3, рр.  404–406.
  12. Hannan J. M. , Ali L., Khaleque J., Akhter M., Flatt P. R., Abdel-Wahab Y. H. Aqueous extracts of husks of Plantago ovata reduce hyperglycaemia in type 1 and type 2 diabetes by inhibition of intestinal glucose absorption. Br J. Nutr.  2006, vol. 96, no. 1, рр. 131–137.
  13. Mehta K., Pantazis P., McQueeb T., Aggarwal B. Antiproliferative effects of curcumin (diferuloilmethane) againts human breast tumor cell lines. Anti-cancer Drugs. 1997, vol. 8, no. 5, рр. 470–481.
  14. Motterlini R, Foresti R, Bassi R, Green CJ. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med. 2000, vol. 28, no. 8, рр. 1303–1312.
  15. Srinivas L. Turmerin: a water soluble antioxidant peptide from turmeric (Curcuma longa). Arch Biochem Biophys. 1992, vol. 292, no. 2, рр. 617–623.

 

Date of the publication 29.06.2016