Novosibirsk State Pedagogical University Bulletin, 2015, vol. 5, no. 6, pp. 184–198
© Gajdarova A. P., Koroshchenko G. A., Anoshin A. V., Aizman R. I., 2015
UDC: 
614 + 615 + 591.14

Distribution of bioelements in certain organs and tissues of normal and diabetic wistar rats

Gajdarova A. P. 1 (Novosibirsk, Russian Federation), Koroshchenko G. A. 1 (Novosibirsk, Russian Federation), Anoshin A. V. 1 (Novosibirsk, Russian Federation), Aizman R. I. 1 (Novosibirsk, Russian Federation)
1 Novosibirsk State Pedagogical University, Novosibirsk, Russian Federation
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Abstract: 

A study of wide spectrum of micro- and macroelements in certain organs and tissues of normal and alloxan-induced diabetic (DM) rats has been performed. It is shown that regardless of the type of tissue, ion content was distributed as follows in descending order: K > Na > Mg > Ca > Fe > Zn > Cu > Mn > Mb ≥ Cr. However, for each element some differences in its distri-bution among organs were observed. In DM rats significant increase of ion concentration has been found: Cu, Fe and Zn – in the kidney; Fe – in the liver; Ca, K, Mg, and Fe – in the pan-creas; Fe – in liver and muscle tissue. Intake of a Curcuma rhizome powder by healthy rats practically did not lead to change of the maintenance of elements in tissues, but in DM rats it caused significant increase of Mg and Zn content only in a kidney. Thus, Curcuma longa prac-tically does not render influence on distribution of bioelements in organs and tissues of rats both in norm, and at DM. Possibly, the bioelements which are included in a plant, do not play an essential role in hypoglycemic effect of a phytopreparation described by us earlier

Keywords: 

micro- and macroelements, diabetes, alloxan, Curcuma, rat, tissues

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For citation:
Gajdarova A. P., Koroshchenko G. A., Anoshin A. V., Aizman R. I. Distribution of bioelements in certain organs and tissues of normal and diabetic wistar rats. Novosibirsk State Pedagogical University Bulletin, 2015, vol. 5, no. 6, pp. 184–198. DOI: http://dx.doi.org/10.15293/2226-3365.1506.19
References: 
  1. Skal’ny A. V. Development of the concept of bioelements and perspectives of bioelementology. Microelements in medicine. 2009, Vol. 10, no. 3–4, pp. 1–6.
  2. Agadzhanjan N. A., Skal’ny A. V. Chemical element in an inhabitancy and an ecological portrait of the person. Moscow, КМК Publ., 2001.
  3. Seljatitsky V. G., Palchikova N. A., Zaksas N. P. Content of microelements in tissue of a liver and a lung of rats with alloxan-induced diabetes. Basic researches. 2012, no. 4–1, pp. 201–205.
  4. Skal’ny A. V., Rudakov I. A. Bioelements in medicine. Moscow, Onyx of 21 centuries Publ., World Publ., 2004.
  5. Sirenko E. V. Influence of multicomponent mixes on a basis of polyethilenglycol on the content of microelements and amino acids in organs and tissues of experimental animals. Bulletin of the Kharkov national university by V. N. Karamzin. 2006, no. 13 (738), pp. 52–55.
  6. Churin B. V., Trunov V. A., Zvereva V. V., Sidorina A. V., Astashov V. V. Macro-microelement  content of a pulmonary tissue at alimentary adiposity. Basic researches. 2012, no. 8–1, pp. 179–183.
  7. Elbekjan K. S., Hodzhajan A. B., Murav’eva A. B. Peculiarities of infringement of macro-and a microelement spectrum of  blood plasma at an experimental diabetes mellitus. Basic researches. 2011, no. 10, pp. 411–413.
  8. Failla M. L., Kiser R. A. Altered Tissue Content and Cytosol Distribution of Trace Metals in Experimental Diabetes. J. Nutr. 1981, vol. 111, pp. 1900–1909.
  9. Dzhafarova R. E., Garaev G. Sh., Dzhafarkulieva Z. S. Effects of an extract of a bilberry ordinary leaves on a dynamic of pathological process at the alloxan-induced diabetes. Basic researches. 2010, no. 4, pp. 36–43.
  10. Mitrofanova I. J., Janitskaja A. V., Butenko D. V. Methodological basis of a choice of vegetative objects as sources of phytopreparations. Basic researches. 2012, no. 10–2, pp. 405–408.
  11. Azhunova T. A., Lemza S. V., Linhoeva E. G. Pharmacotherapeutic efficiency of complex vegetative substance  at an experimental diabetes. Bulletin of the East Siberian Scientific Center of the Russian Academy of Medical Science. 2011, no. 1 (77), pp. 79–83.
  12. Lutomski J., Kedzia B., Debska W. Effect of an alcohol extract and of active ingredients from Curcuma longa on bacteria and fungi. Planta Med. 1974, Vol. 26, no. 1, pp. 9–19.
  13. Mehta K., Pantazis P., McQueeb T., Aggarwal B. Antiproliferative effects of curcumin (diferuloilmethane) against human breast tumor cell lines. Anti-cancer Drugs. 1997, Vol. 8, no. 2, pp. 470–481.
  14.   Aizman R. I, Koroshchenko G. A., Gerasev A. D., Gajdarova A. P. Using of nonmedicinal preparations for correction of carbohydrate and water-mineral balance at its infringements. Novosibirsk, Novosibirsk State Pedagogical University Publ., 2014, 90 p.
  15. Britkova A. D. Developmental changes of microelements content in organs and tissues of animals. Bulletin OGU. 2006, no. 2–2 (52), pp. 7–12.
  16. Sullivan J. L. Iron and the sex difference in heart diseaserisk. Lancet. 1981, Vol. 1, no. 3, pp. 1293–1294.
  17. Aizman R. I, Koroshchenko G. A., Gajdarova A. P., Subotjalov M. A., Lukanina S. N., Sakharov A. V. Mechanisms of action of a rhizome of plant Curcuma longa powder on carbohydrate balance at the alloxan-induced diabetic rats. Bulletin of the Siberian medicine. 2014, no. 13 (6), pp. 105–112.
  18. Cai L. Metallothionein as an adaptive protein prevents diabetes and its toxicity. Nonlinearity in Biology, Toxicology and Medicine. 2004, no. 2, pp. 89–103.
  19. Madsen-Bouterse S. A., Zhong Q., Mohammad G., Ho Y. S., Kowluru R. A. Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase. Free Radic. Res. 2010, no. 44 (3), pp. 313–321.
  20. Aizman R. I, Gerasev A. D., Koroshchenko G. A, Lukanina S. N. Using of natural zeolites in medical and biologic researches. Biological science and education in pedagogical high schools: materials of the IV All-Russia. Conf. "The problems of biological science and education ped. institutions of higher education", 28–29 April, 2005. Ed. L. G. Vartapetova, R. I. Aizman, O. B. Makarova. Novosibirsk, Novosibirsk State Pedagogical University Publ., 2005, Issue 4, pp. 222–223.
  21. Aizman R. I., Turner A. Ja. Developmental features of ionregulating functions of kidneys. Human Physiology. 1989, no. 4, pp. 78–86.
  22. Natochin Ju. V. Ionregulating kidney function. Leningrad, Science Publ., 1976.
  23. Koroshchenko G. A, Subotjalov M. A, Gerasev A. D., Aizman R. I. Influence of a rhizome of plant Сurcuma longa on a carbohydrate balance of rats in experiment. The Siberian Scientific Medical Journal. 2011, no. 31 (3), pp. 92–96.
  24. Koroshchenko G. A., Gajdarova A. P., Aizman R. I., Subotjalov M. A. Possibility of using of phytopreparations for maintenance of a homeostasis of an organism at a pathology. Ukrainian Biopharmaceptic Journal. 2014, no. 4 (33), pp. 45–49.
  25. Gajdarova A. P., Koroshchenko G. A., Aizman R. I. Influence of Curcuma and Curcumin on a carbohydrate balance at the alloxan-induced diabetes at rats. Modern problems of science and education. 2014, no. 5, p. 597. Available at: http://www.science-education.ru/119-14779 (accessed 27.10.15)
Date of the publication 20.12.2015