Science for Education Today, 2025, vol. 15, no. 5, pp. 242–267
© Darenskaya M. A., Yuzvak N. A., Prokhorova Z. V., Rychkova L. V., Kolesnikov S. I., Semenova N. V., Votineva A. S., Kolesnikova L. I., 2025
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Evaluation of psychoemotional status and oxidative stress indicators in senior school-age boys with exogenous-constitutional obesity

Darenskaya M. A. 1 (Irkutsk, Russian Federation), Yuzvak N. A. 1 (Irkutsk, Russian Federation), Prokhorova Z. V. 1 (Irkutsk, Russian Federation), Rychkova L. V. 1 (Irkutsk, Russian Federation), Kolesnikov S. I. 1 (Irkutsk, Russian Federation), Semenova N. V. 1 (Irkutsk, Russian Federation), Votineva A. S. 1 (Irkutsk, Russian Federation), Kolesnikova L. I. 1 (Irkutsk, Russian Federation)
1 Scientific Centre for Family Health and Human Reproduction Problems
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Abstract: 

Introduction. Obesity in school age, in addition to metabolic and biochemical disorders, can affect the psychosocial adjustment of adolescents in the educational process. A significant cohort of patients is made up of senior boys. The aim of the article is to assess the indicators of psychoemotional status, oxidative stress and their relationship in senior school-age boys with exogenous-constitutional obesity to justify the need to improve health-preserving programs.
Materials and Methods. The work used methods of clinical examination, questionnaires, analytical, fluorometric, enzyme immunoassay and statistical research methods.
Results. The analysis of coping strategies in senior school-age boys with exogenous-constitutional obesity revealed a decrease in the frequency of patients with relatively productive mechanisms in cognitive, emotional and behavioral coping strategies. In this group, a decrease in the number of children with a low level of anxiety, hostility, irritation, negativism and guilt has been detected. The study also revealed individuals with a high level of these reactions. At the biochemical level, boys with exogenous-constitutional obesity showed higher rates of DNA destruction - 8-OHdG and the oxidized form of glutathione (against the background of reduced values of its reduced form). The study found significant correlations between the indicators of the level of anxiety and α-tocopherol, the level of depression and 8-OhdG, the level of irritation and 8-OhdG, the feeling of guilt and 8-OhdG, emotional coping and GSSG, the level of negativism and GSH.
Conclusions. Negative changes in psychoemotional status, as well as high intensity of oxidative stress reactions in senior school-age boys with obesity determine the need to improve health-preserving programs in the context of the educational process.

Keywords: 

Exogenous-constitutional obesity; Boys; Senior school age; Psychoemotional state; Coping strategies; Anxiety; Depression; Oxidative stress; Antioxidant protection; Educational process

For citation:
Darenskaya M. A., Yuzvak N. A., Prokhorova Z. V., Rychkova L. V., Kolesnikov S. I., Semenova N. V., Votineva A. S., Kolesnikova L. I. Evaluation of psychoemotional status and oxidative stress indicators in senior school-age boys with exogenous-constitutional obesity. Science for Education Today, 2025, vol. 15, no. 5, pp. 242–267. DOI: http://dx.doi.org/10.15293/2658-6762.2505.11
References: 
  1. Dakhkilgova Kh. T. Childhood obesity: The current state of the problem. Pediatric Nutrition, 2019, vol. 17 (5), pp. 47-53. (In Russian) URL: https://www.elibrary.ru/item.asp?id=41867836  DOI: https://doi.org/10.20953/1727-5784-2019-5-47-53 
  2. Romanitsa A. I., Polyakov V. M., Pogodina A. V., Myasishchev N. A., Klimkina Yu. N., Rychkova L. V. Obese adolescent: Social and psychological portrait. Acta Biomedica Scientifica, 2020, vol. 5 (6), pp. 179-187. (In Russian) URL: https://www.elibrary.ru/item.asp?id=44536228  DOI: https://doi.org/10.29413/ABS.2020-5.6.21  
  3. Davison G. M., Monocello L. T., Lipsey K., Wilfley D. E. Evidence base update on behavioral treatments for overweight and obesity in children and adolescents. Journal of Clinical Child & Adolescent Psychology, 2023, vol. 52 (5), pp. 589-603. DOI: https://doi.org/10.1080/15374416.2023.2251164
  4. Novikova I. I., Romanenko S. P., Lobkis M. A., Gavrish S. M., Semenikhina M. V., Sorokina A. V., Shevkun I. G. Assessment of risk factors for overweight and obesity in schoolchildren for the development of effective prevention programs. Science for Education Today, 2022, vol. 12 (3), pp. 132-148. (In Russian) URL: https://www.elibrary.ru/item.asp?id=48762164 DOI: http://dx.doi.org/10.15293/2658-6762.2203.07 
  5. Rychkova L. V., Ajurova Z. G., Pogodina A. V., Kosovtseva A. S. Risk factors for obesity in adolescents of ethnic groups in rural areas of the Republic of Buryatia: A cross-sectional study. Current Pediatrics, 2017, vol. 16 (6), pp. 509-515. (In Russian) URL: https://www.elibrary.ru/item.asp?id=32274735  DOI: http://dx.doi.org/10.15690/vsp.v16i6.1824 
  6. Kochetova Y. Y., Starchikova M. V., Bendrikova A. Y., Repkina T. V. Evaluating the impact of stress factors, inadequate nutrition and low physical activity on schoolchildren’s health. Science for Education Today, 2020, vol. 10 (5), pp. 211-225. (In Russian) URL: https://www.elibrary.ru/item.asp?id=44193032   DOI: http://dx.doi.org/10.15293/2658-6762.2005.12  
  7. Rychkova L. V., Pogodina A. V., Ayurova Zh. G., Klimkina Ju. N. Obesity and health-related quality of life in adolescents from ethnic groups of rural areas of Buryatia, Russia. Bulletin of Siberian Medicine, 2018, vol. 17 (3), pp. 105-114. (In Russian) URL: https://www.elibrary.ru/item.asp?id=36282578   DOI: http://dx.doi.org/10.20538/1682-0363-2018-3-105-114
  8. Moradi M., Mozaffari H., Askari M., Azadbakht L. Association between overweight/obesity with depression, anxiety, low self-esteem, and body dissatisfaction in children and adolescents: A systematic review and meta-analysis of observational studies. Critical Reviews in Food Science and Nutrition, 2020, vol. 62 (2), pp.  555-570. DOI: https://doi.org/10.1080/10408398.2020.1823813
  9. Dimitratos S. M., Swartz J. R., Laugero K. D. Pathways of parental influence on adolescent diet and obesity: A psychological stress–focused perspective. Nutrition Reviews, 2022, vol. 80 (7), pp. 1800-1810. DOI: https://doi.org/10.1093/nutrit/nuac004

10. Pogodina A. V., Astakhova T. A., Lebedeva L. N., Rychkova L. V. Eating patterns and risk of eating disorders in adolescents. Problems of Nutrition, 2024, vol. 93 (3), pp. 31-40. URL: https://www.elibrary.ru/item.asp?edn=srxpnf   DOI: https://doi.org/10.33029/0042-8833-2024-93-3-31-40 

11. Pogodina A. V., Astakhova T. A., Lebedeva L. N., Rychkova L. V. Body dissatisfaction and associated factors in normal weight adolescents. Pediatrician (St. Petersburg), 2024, vol. 15 (1), pp. 91-100. DOI: https://doi.org/10.17816/PED15191-100

12. Mallan K. M., Daniels L. A., Nicholson J. Obesogenic eating behaviors mediate the relationships between psychological problems and BMI in children. Obesity, 2017, vol. 25 (5), pp. 928-934. DOI: https://doi.org/10.1002/oby.21823

13. Förster L. J., Vogel M., Stein R., Hilbert A., Breinker J. L., Böttcher M., Kiess W., Poulain T. Mental health in children and adolescents with overweight or obesity. BMC Public Health, 2023, vol. 23 (1), pp. 135. DOI: https://doi.org/10.1186/s12889-023-15032-z 

14. Povarova O. V., Gorodetskaya E. A., Kalenikova E. I., Medvedev O. S. Metabolic markers and oxidative stress in children’s obesity pathogenesis. Russian Bulletin of Perinatology and Pediatrics, 2020, vol. 65 (1), pp. 22-29. (In Russian) URL: https://www.elibrary.ru/item.asp?edn=diqrjr   DOI: https://doi.org/10.21508/1027-4065-2020-65-1-22-29 

15. Kolesnikova L. I., Rychkova L. V., Darenskaya M. A., Gavrilova O. A., Ayurova Zh. G., Grebenkina L. A., Semenova N. V., Kolesnikov S. I. Peculiarities of pro- and antioxidant status in adolescents, representatives of two ethnic groups with exogenous-constitutional 1st-degree obesity. Pediatria, 2020, vol. 99 (5), pp. 201-206. (In Russian) URL: https://www.elibrary.ru/item.asp?id=43989606   DOI: https://doi.org/10.24110/0031-403X-2020-99-5-201-206 

16. Usman M., Woloshynowych M., Britto J.C., Bilkevic I., Glassar B., Chapman S., Ford-Adams M.E., Desai A., Bain M., Tewfik I., Volpi E.V. Obesity, oxidative DNA damage and vitamin D as predictors of genomic instability in children and adolescents. International Journal of Obesity, 2021, vol. 45 (9), pp. 2095-2107. DOI: https://doi.org/10.1038/s41366-021-00879-2 

17. Darenskaya M. A., Yuzvak N. A., Rychkova L. V., Kolesnikov S. I., Semenova N. V., Prokhorova Zh. V., Kolesnikova L. I. Ethnic aspects of obesity in adolescents: Endogenous intoxication, activity of antioxidant enzymes, proteins' and DNA oxidative damage. Problems of Nutrition, 2025, vol. 94 (3), pp. 59-68. (In Russian) URL: https://www.elibrary.ru/item.asp?id=82776379 DOI: https://doi.org/10.33029/0042-8833-2025-94-3-00-00

18. Darenskaya M. A., Rychkova L. V., Kolesnikov S. I., Kravtsova O. V., Semenova N. V., Brichagina A. S., Kolesnikova L. I. Changes in lipid peroxidation system during standard therapy for exogenous constitutional obesity in adolescents of different sex. Pediatric Nutrition, 2022, vol. 20 (1), pp. 5-11. (In Russian) URL: https://www.elibrary.ru/item.asp?id=48434079

19. Lupu A., Fotea S., Jechel E., Starcea I. M., Ioniuc I., Knieling A., Salaru D. L., Sasaran M. O., Cirstea O., Revenco N., Mihai C. M., Lupu V. V., Nedelcu A. H. Is oxidative stress-antioxidants imbalance the physiopathogenic core in pediatric obesity? Frontiers in Immunology, 2024, vol. 15, pp. 1394869. DOI: https://doi.org/10.3389/fimmu.2024.1394869 

20. Katrenčíková B., Vaváková M., Paduchová Z., Nagyová Z., Garaiova I., Muchová J., , Ďuračková Z., Trebatická J. Oxidative stress markers and antioxidant enzymes in children and adolescents with depressive disorder and impact of omega-3 fatty acids in randomised clinical trial. Antioxidants, 2021, vol. 10 (8), pp. 1256. DOI: https://doi.org/10.3390/antiox10081256 

21. Nuzzo D. Role of natural antioxidants on neuroprotection and neuroinflammation. Antioxidants, 2021, vol. 10 (4), pp. 608. DOI: https://doi.org/10.3390/antiox10040608 

22. Vasyukova O. V., Okorokov P. L., Malievskiy O. A., Neimark A. E., Zorin E. A., Yashkov Y. I., Burmitskaya Yu. V., Kopytina D. A., Bezlepkina O. B., Peterkova V. A. Clinical guidelines “Obesity in children”. Obesity and metabolism, 2024, vol. 21 (4), pp. 439-453. (In Russian) URL: https://www.omet-endojournals.ru/jour/article/view/13194 URL: https://www.elibrary.ru/item.asp?id=79564174  DOI: https://doi.org/10.14341/omet13194 

23. Dzhumagaziev A. A., Shilina N. M., Bezrukova D. A., Otto N. Yu., Sosinovskaya E. V., Filipchuk A. V. External factors contributing to the development of constitutional exogenous obesity in children. Nutrition Issues, 2025, vol. 94 (1), pp. 37-49. (In Russian) URL: https://www.elibrary.ru/item.asp?id=80500265   DOI: https://doi.org/10.33029/0042-8833-2025-94-1-37-49 

24. Anufrieva E. V., Kovtun O. P., Kiiaev A. V., Zaykova I. O., Neupokoeva L. Yu. Comprehensive approach to organizing care delivery to overweight school-aged children. Social Aspects of Population Health, 2022, vol. 68 (2), pp. 6. (In Russian) URL: https://www.elibrary.ru/item.asp?id=48613337   DOI: https://doi.org/10.21045/2071-5021-2021-68-2-6   

25. Karpova E. A., Drynkina T. I. Stress resistance, coping strategies and managing change under uncertainty. Uchenye Zapiski of St. Petersburg University of Management Technologies and Economics, 2022, vol. 3, pp. 245-254. (In Russian) URL: https://www.elibrary.ru/item.asp?id=49489227   DOI: https://doi.org/10.35854/2541-8106-2022-3-245-254  

26. Flitman E. D., Yakubova L. N., Kholmogorova A. B., Vasykova O. V. Obesity and depression in children and adolescents: The problem of comorbidity and prevention. Counseling Psychology and Psychotherapy, 2024, vol. 32 (3), pp. 8-27. (In Russian) URL: https://www.elibrary.ru/item.asp?id=76842396  DOI: https://doi.org/10.17759/cpp.2024320301  

27. Shtina I. E., Valina S. L., Ustinova O. Yu., Eisfeld D. A. Characteristics of autonomic status and school anxiety in schoolchildren with increased body mass index. Obesity and Metabolism, 2022, vol. 19 (1), pp. 62-73. (In Russian) URL: https://www.elibrary.ru/item.asp?id=48495720  DOI: https://doi.org/10.14341/omet12725 

28. Gwizda G., Horaczyńska-Wojtaś A., Mielnik-Niedzielska G., Kasprzyk A., Chmielik L. P., Niedzielski A. Psychogenic hearing loss in children and adolescents. Diagnosis and psychotherapy. Annals of Medicine, 2025, vol. 57 (1), pp. 2447412. DOI: https://doi.org/10.1080/07853890.2024.2447412 

29. Flint S. W., Vázquez-Velázquez V., Le Brocq S., Brown A. The real-life experiences of people living with overweight and obesity: A psychosocial perspective. Diabetes, Obesity and Metabolism, 2025, vol. 27 (2), pp. 35-47. DOI: https://doi.org/10.1111/dom.16255 

30. Sarf E. A., Bel’skaya L. V. Assessing the level of psycho-emotional stress in students using biochemical analysis of saliva. Science for Education Today, 2023, vol. 13 (4), pp. 218-240. (In Russian) URL: https://www.elibrary.ru/item.asp?id=54390180  DOI: http://dx.doi.org/10.15293/2658-6762.2304.10 

31. Donmez-Altuntas H., Sahin F., Bayram F., Bitgen N., Mert M., Guclu K., Hamurcu Z., Arıbas S., Gundogan K., Diri H. Evaluation of chromosomal damage, cytostasis, cyto toxicity, oxidative DNA damage and their association with body mass index in obese subjects. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2014, vol. 771, pp. 30-36. DOI: https://doi.org/10.1016/j.mrgentox.2014.06.006 

32. Włodarczyk M., Nowicka G. Obesity, DNA damage, and development of obesity-related diseases. International Journal of Molecular Sciences, 2019, vol. 20 (5), pp. 1146. DOI: https://doi.org/10.3390/ij ms20051146

33. D'Alessandro A., Di Felice G., Manco M., Pastore A., Pezzi S., Mariani M., Fintini D., Onetti Muda, Porzio O. Study of the association between thiols and oxidative stress markers in children with obesity. Nutrients, 2022, vol. 14 (17), p. 3637. DOI: https://doi.org/10.3390/nu14173637 

34. Alkazemi D., Rahman A., Habra B. Alterations in glutathione redox homeostasis among adolescents with obesity and anemia. Scientific Reports, 2021, vol. 11 (1), pp. 3034. DOI: https://doi.org/10.1038/s41598-021-82579-5 

35. Lee A. R. Y. B., Tariq A., Lau G., Tok N. W. K., Tam W. W. S., Ho C. S. H. Vitamin E, Alpha-Tocopherol, and Its Effects on Depression and Anxiety: A Systematic Review and Meta-Analysis. Nutrients, 2022, vol. 14 (3), pp. 656. DOI: https://doi.org/10.3390/nu14030656

36. Kuchma V. R., Tkachuk E. A., Globenko N. E. Nutrition problems of modern schoolchildren, including children with disorders of the psychological development. Hygiene and Sanitation, 2022, vol. 101 (11), pp. 1372-1378. (In Russian) URL: https://www.elibrary.ru/item.asp?id=49985011  DOI: https://doi.org/10.47470/0016-9900-2022-101-11-1372-1378  

37. Coello K., Mäkinen I. J. O., Kjærstad H. L., Faurholt-Jepsen M., Miskowiak K. W., Poulsen H. E., Vinberg M., Kessing L. V. Oxidation of DNA and RNA in young patients with newly diagnosed bipolar disorder and relatives. Translational Psychiatry, 2024, vol. 14 (1), pp. 81. DOI: https://doi.org/10.1038/s41398-024-02772-8

38. Lievanos-Ruiz F. J., Fenton-Navarro B. Enzymatic biomarkers of oxidative stress in patients with depressive disorders. A systematic review. Clinical Biochemistry, 2024, vol. 130, pp. 110788. DOI: https://doi.org/10.1016/j.clinbiochem.2024.110788 

 

Date of the publication 31.10.2025