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Plasma free amino acid profile in patients with oral cancer
Metabolic changes in patients with cancer lead to alterations in their amino-acid balances. Thus, amino acid profiles may be useful as biomarkers of cancers. This study was conducted to analyze amino-acid profiles in plasma in order to elucidate differences between cancer patients and controls. We analyzed the baseline serum levels of 19 amino acids in 15 patients with II and III stages of oral cancer with no metabolic alterations or other concomitant disorders and compared the results with a control group. Compared with the control group, patients with oral cancer had significant differences in lysine, ornithine, aspartic acid, serine, glycine, glutamic acid, cysteine, leucine, tyrosine, and phenylalanine. This study revealed significant differences in plasma amino acid profiles between cancer patients and controls. The development of a cancer alters plasma amino-acid profiles and the pattern of change differs between different stages of oral cancer. Plasma amino-acid profiling might therefore be useful for the early detection of cancer.
amino acid profiles, plasma, screening, cancer
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