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Some aspects of infectious-allergic and toxic hepatitis and cirrhosis
Experimental studies have been put on white rats and guinea pigs. Liver injury induced by two models hepatitis and liver cirrhosis, administration of hepatotoxic alkaloid – heliotrin and dysentery toxin, which is a dead, dried culture of Shiga bacilli.
When administered heliotrin and dysentery toxin observed severe damage liver tissue. On the background of circulatory disturbances expressed some of the animals met foci of necrosis of the liver lobules, often around the central veins, and significant lymphocytic infiltration hysteocitar that could be interpreted as a sign of delayed hypersensitivity.
Along with pathologic changes of the liver changes were observed T and B cell population, demonstrating functional changes characteristic of chronic hepatitis and liver cirrhosis. The most important factor in the genesis of liver cirrhosis – damage (necrosis) of hepatocytes caused by a direct toxic effect, as well as autoimmune processes. Sensitization of immune to the body's own tissues – an important factor in the pathogenesis and cirrhosis develops in patients with viral hepatitis B, C and D.
liver , autoimmune destruction, hepatitis, cirrhosis
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